Simvastatin
Basic Information
| Item | Value |
|---|---|
| DrugBank ID | DB00641 |
| Evidence Level | L5 (Computational Prediction) |
| Number of Predicted Indications | 43 |
Predicted Indications (TxGNN)
The following are potential new indications predicted by the TxGNN model. Higher scores indicate higher predicted relevance.
| # | Indication | Source |
|---|---|---|
| 1 | familial hypercholesterolemia | KG + DL |
| 2 | brain stem infarction | KG + DL |
| 3 | cholesterol-ester transfer protein deficiency | KG + DL |
| 4 | hypercholesterolemia, autosomal dominant | KG + DL |
| 5 | hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency | KG + DL |
| 6 | HIV infectious disease | KG + DL |
| 7 | ABri amyloidosis | KG + DL |
| 8 | neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter | KG + DL |
| 9 | fibroma of prostate | KG + DL |
| 10 | feline acquired immunodeficiency syndrome | KG + DL |
| 11 | simian immunodeficiency virus infection | KG + DL |
| 12 | cerebral artery occlusion | KG + DL |
| 13 | benign reproductive system neoplasm | KG + DL |
| 14 | Brenner tumor | KG + DL |
| 15 | prostate cancer/brain cancer susceptibility | KG + DL |
| 16 | benign prostate phyllodes tumor | KG + DL |
| 17 | cerebral arterial disease | KG + DL |
| 18 | hyperlipidemia due to hepatic triglyceride lipase deficiency | KG + DL |
| 19 | male reproductive organ cancer | KG + DL |
| 20 | hypolipoproteinemia (disease) | KG + DL |
| 21 | generalized atherosclerosis | KG + DL |
| 22 | cerebral atherosclerosis | KG + DL |
| 23 | prostate leiomyoma | KG + DL |
| 24 | prostate neoplasm | KG + DL |
| 25 | coronary atherosclerosis | KG + DL |
| 26 | MRI defined brain infarct | KG + DL |
| 27 | familial hyperlipidemia | KG + DL |
| 28 | hyperlipidemia | KG + DL |
| 29 | female breast carcinoma | KG + DL |
| 30 | cholesterol embolism | KG + DL |
| 31 | ABeta amyloidosis | KG + DL |
| 32 | intracerebral hemorrhage | KG + DL |
| 33 | glaucoma | KG + DL |
| 34 | hyperalphalipoproteinemia | KG + DL |
| 35 | cardiac tamponade | KG + DL |
| 36 | sitosterolemia | KG + DL |
| 37 | duodenal obstruction | KG + DL |
| 38 | hypertriglyceridemia, familial | KG + DL |
| 39 | familial chylomicronemia syndrome | KG + DL |
| 40 | fish eye disease | KG + DL |
| 41 | paratenonitis | KG + DL |
| 42 | anomalous left coronary artery from the pulmonary artery | KG + DL |
| 43 | calcific tendinitis | KG + DL |
Disclaimer
These predictions are for research purposes only and do not constitute medical advice. Clinical validation is required before any clinical application.